Amiloride-Sensitive Sodium Channels: Physiology and by Dale J. Benos (Eds.)

By Dale J. Benos (Eds.)

Sodium reabsorbing epithelia play an important function in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step technique: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated by way of numerous diversified hormones. The sodium channels additionally play an important function in a couple of sickness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and practical variety presents the 1st in-depth trade of principles pertaining to those sodium channels, their legislation and involvement in general and pathophysiological occasions. Key positive aspects * Summarizes present kingdom of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal rules of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * offers principles on sodium channels and illness

Show description

Read or Download Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity PDF

Similar basic sciences books

diFiore's Atlas of Histology with Functional Correlations (Point (Lippincott Williams & Wilkins))

DiFiore's Atlas of Histology with practical Correlations, 11th variation, explains simple histology innovations via full-color, schematic illustrations. those illustrations are supplemented through greater than 450 digitized full-color on-line photomicrographs of histological photographs. half One explains tissues and their dating to their platforms; half addresses organs similarly.

Seldin and Giebisch's The Kidney, Fifth Edition: Physiology & Pathophysiology

A vintage nephrology reference for over 25years, Seldin & Giebisch's The Kidney, is the said authority on renal body structure and pathophysiology. during this fifth variation, such new and strong disciplines as genetics and phone biology were deployed to deepen and widen extra the explanatory framework.

Erythropoietin

The publication includes a sequence of updated overview articles at the body structure and pathophysiology of the keep an eye on of the creation of purple cells via the hormone erythropoietin. additionally, the implications are mentioned of preliminary medical trials utilizing recombinant human erythropoietin (rhuEpo) within the therapy of the anemia of renal failure.

Extra info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

Sample text

Shlyonsky, V. , and Benos, D. J. (1997). Regulation of ENaC by the amino terminus of a-rENaC. Physiologist 40, A-4 (abstr. 5). , Henry, P. , and Rotin, D. (1996). WW domains of Nedd 4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle’s syndrome. EMBO J. 15, 2371-2380. Stutts, M. , Canessa, C . , Olsen, J. , Cohn, J. , Rossier, B. , and Boucher, R. C. (1995). CFTR as a CAMP-dependent regulator of sodium channels. Science 269,847-850. Stutts, M. , Rossier, B. , and Boucher, R.

A greater amiloride-sensitive current was observed in oocytes expressing all three subunits than in those expressing abENaC alone. 5 ng of each cRNA exhibited a fivefold increase in current following 48 h of expression. Results are 2SEM. Reprinted with permission from Fuller e l al. 1995. was expressed in oocytes. Intracellular PKA consensus sequences have been identified only in the y subunits of the rat and Xenopus isoforms; the human ENaC has no predicted PKA-sensitive sites (Garty and Palmer, 1997).

1998). , 1996). , 1993). , 1998). In abENaC, four of the proposed consensus sites for PKCdependent phosphorylation are predicted to be intracellular. , 1993; Yanase and Handler, 1986). , 1996). , 1995). This observation 8 C. M. Fuller et al. may reflect a specific difference in how abENaC is regulated when expressed by itself; however, similar experiments on the chimeric bENaC/rENaC channel needed to address this question have not yet been performed. 111. THE C TERMINUS OF abENaC: A KINETIC SWITCH?

Download PDF sample

Rated 4.31 of 5 – based on 32 votes