Adenoviruses: Model and Vectors in Virus-Host Interactions: by G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr.

By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the prior years have obvious fast growth within the box of adenovirus examine. in addition, adenoviruses have attracted substantial curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity offers with the immune method, oncogenesis and gene treatment.

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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy

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1999; Storch and Braulke 2001 Heilker et al. 1999; Puertollano et al. 2001; Zhu et al. 2001; Storch and Braulke 2001 Petris et al. 1998; Francis et al. 1999 Hunziker and Furney 1994 Heilker et al. 1999 Heilker et al. 1999 Heilker et al. 1999 Heilker et al. 1999 Heilker et al. 1999 Banting and Ponnambalam 1997 Heilker et al. ,.. w Er on (l) S. "t:I .... ;:=; • 0 ::l (l) p.. g. g. EGFR ERGlC-53 VlP36 Cl- and CD-MPR CD-MPR Lysosomal hydrolases Protein E E E TlP47 TGN/EE L PACS-l Adaptor binding TGN Destination Carroll et al.

I (Ad'O) ~ous E3-0RFs 'nsubge.... 7K Subgroup A 1,>¥""",.. I[I:: · :l --Z,··:: .. 8K Subgroup E I" """"".. 5K 147K C . encodng transmembr8J'1e proleins present in iiIIl or in the ma;on:y of subgenera . ORF. encooog cylooolic proteins 0 Fig. 1 E3 region coding capacity of representative members of Ad subgenera A-F. Open reading frames (ORFs) are indicated as bars and are drawn to scale. The shading code is depicted below the figure. ORFs encoding transmembrane proteins are indicated by filled boxes and bold characters, and ORFs encoding cytosolic proteins are represented by open boxes.

For other abbreviations and details see text. Palmitoylation Man-6-P FW Acidic cluster Ubiquitin KKFF KRFY Other sorting signals Signal (s) Table 2 (continued) ~ ~ s·'" ~ i:l §: ~ """ """ Immune Evasion by Adenovirus E3 Proteins 45 TGN utilizing these sorting signals. For instance, TGN localization of TGN38 and furin was shown to depend on YXX motifs (see below) in their cytoplasmic tails which mediate their retrieval from the cell surface (Table 2). The retention of TGN38 in the TGN is mediated by its TMD (Banting and Ponnambalam 1997), whereas an acidic cluster motif with a casein kinase II phosphorylation site is required for furin localization in the Golgi (Molloy et al.

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